伊豫田 拓也（Takuya Iyoda）

職名	教授　(Professor)
学位	博士（理学）
専門分野	分子病態学 細胞外マトリックス/結合組織学 分子免疫学
略歴	東邦大学理学部生物分子科学科/分子免疫学　卒 東邦大学理学研究科分子医学部門/分子免疫学　博士課程 修了 テネシー大学獣医学部生体医科学・診断科学科/病態生理学　ポスドク 福岡大学医学部医学科/薬理学　助教 東京理科大学薬学部生命創薬科学科/分子病態学　助教 東京理科大学薬学部生命創薬科学科/分子病態学　講師
研究者データベース	詳細はこちらから
SDGsの取組み

主な研究課題

慢性炎症関連疾患を巧くコントロールする技術の創生

がんや動脈硬化を含む様々な加齢性疾患の基礎病態として、近年慢性炎症が注目を集めています。炎症反応は一種の生体防御応答であり、その惹起と収束という背反する２つのステージから成りますが、この両ステージの調節に中心的に関わる細胞がマクロファージです。一方で生体を構成する細胞の殆どは結合組織（細胞外マトリックス）への「然るべき細胞接着」を通じ、発現する細胞機能の正常性を維持しています。そこで加齢や病態の進行に伴う細胞外マトリックス環境の変化に注目し、これがマクロファージを含む種々病態構成細胞に異常をもたらす仕組みの解明と、これを標的として慢性炎症関連疾患を巧くコントロールする技術の創生を目指しています。

・令和7-9 年 科研費・基盤(C),「炎症性テネイシンC 内生理活性配列を介した腎細胞機能調節が、腎炎形成に果たす役割」
・令和5-6 年 日本イーライリリー教育研究助成, 「細胞接着シグナルを介した中枢マクロファージ系細胞機能の調節がアルツハイマー型認知症に及ぼす影響」
・平成29-31年 科研費・基盤(C),「微小接着環境の変化がもたらす細胞機能異常を標的とした革新的動脈硬化治療法の開発」
・平成27-28年 科研費・若手(B),「細胞外マトリックス環境変化誘導性のマクロファージ泡沫化を標的とする新規動脈硬化療法」
・平成25年 武田科学振興財団研究助成・薬学研究奨励,「神経芽腫治療を標的とした新規高効率分化誘導療法の創成」
・平成20-21年 科研費・若手(B),「貪食細胞の機能発現においてイオン輸送体が果たす役割」

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主な著書・論文

• Iyoda T, ... Nakagawa Y, Shimano H, Fukai F, Bioactive TNIIIA2 sequence in tenascin-C is responsible for macrophage foam cell transformation; Potential of FNIII14 peptide derived from fibronectin in suppression of atherosclerotic plaque formation. Int J Mol Sci, 25(3), 1825-, doi: 10.3390/ijms25031825. (2024).
• Inouye S, ... Iyoda T, ... Akagi R, Heat shock-induced heme oxygenase-1 expression in a mouse hepatoma cell line is dependent on HSF1 and modified by NRF2 and BACH1. Genes to Cells, 12, 719-, doi: 10.1111/gtc.12986. (2022).
• Fujita M, ... Iyoda T, ... Fukai F, Induction of cellular senescence in fibroblasts through beta1-integrin activation by tenascin-C-derived peptide and its protumor effect. Am J Cancer Res, 11(9), 4364-, ISSN: 2156-6976/ajcr0136961. (2021).
• Kawano Y, ... Iyoda T, ... Hanawa T, Wound healing promotion by hyaluronic acid: Effect of molecular weight on gene expression and in vivo wound closure. Pharmaceuticals, 14(4), 301-, doi: 10.3390/ph14040301. (2021).
• Fujita M, Sasada M, Iyoda T, ... Fukai F, Anoikis resistance conferred by tenascin-C-derived peptide TNIIIA2 and its disruption by integrin inactivation. Biochem Biophys Res Commun. 536, 14-, doi: 10.1016/j.bbrc.2020.12.050. (2021).
• Iyoda T, Motomichi F, Fukai F, Biologically active TNIIIA2 region in tenascin-C molecule: A major contributor to elicit aggressive malignant phenotypes from tumors/tumor stroma. Front Immunol, 11:610096, doi: 10.3389/fimmu.2020.610096. (2020).
• Itagaki K, ... Iyoda T, ... Fukai F, Exposure of the cryptic de-adhesive site FNIII14 in fibronectin molecule and its binding to membrane-type eEF1A induce migration and invasion of cancer cells via β1-integrin inactivation, An J Cancer Res, 10(11), 3990-, ISSN:2156-6976/ajcr0120898 (2020).
• Fujita M, Sasada M, Iyoda T, ... Fukai F, Involvement of integrin-activating peptides derived from tenascin-C in cancer aggression and new anticancer strategy using the fibronectin-derived integrin-inactivating peptide, Molecules, 25(14), 3239-, doi: 10.3390/molecules25143239. (2020).
• Sasada M, Iyoda T, ... Fukai F, Inactivation of beta1 integrin induces proteasomal degradation of Myc oncoproteins. Oncotarget, 10(48), 4960-, doi: 10.18632/oncotarget.27131. (2019).
• Fujita M, Yamamoto T, Iyoda T, ... Fukai F, Autocrine production of PDGF stimulated by the tenascin-C-derived peptide TNIIIA2 induces hyper-proliferation in glioblastoma cells. Int J Mol Sci, 20(13), 3183-, doi: 10.3390/ijms20133183. (2019).
• Fujita M, Yamamoto T, Iyoda T, ... Fukai F, Aggressive progression in glioblastoma cells through potentiated activation of integrin α5β1 by the tenascin-C-derived peptide TNIIIA2, Mol Cancer Ther, 18(9), 1649-, doi: 10.1158/1535-7163.MCT-18-1251. (2019).
• Fujita M, Ito-Fujita Y, Iyoda T, ... Fukai F, Suzuki H, Peptide TNIIIA2 derived from Tenascin-C contributes to malignant progression in colitis-associated colorectal cancer via beta1-integrin activation in fibroblast. Int J Mol Sci, 20(11), 2752-, doi: 10.3390/ijms20112752. (2019).
• Otsuka K, Sasada M, Iyoda T, ... Fukai F, Combining peptide TNIIIA2 with all-trans retinoic acid accelerates N-Myc protein degradation and neuronal differentiation in MYCN-amplified neuro-blastoma cells. Am J Cancer Res, 9(2), 434-, ISSN:2156-6976/ajcr0090684. (2019).
• Iijima K, ... Iyoda T, ... Hashizume M, Control of cell adhesion and proliferation utilizing polysaccharide composite film scaffolds. Colloids Surf. B Biointerfaces, 160, 228-, doi: 10.1016/j.colsurfb.2017.09.025. (2017).
• Suzuki H, Sasada M, Iyoda T, ... Fukai F, The promoting effect of extracellular matrix peptide TNIIIA2 derived from tenascin-C in colon cancer cell infiltration. Int J Mol Sci, 18(1), 1-, doi: 10.3390/ijms18010181 (2017).
• Iyoda T, Nagamine Y, ... Fukai F, Coadministration of the FNIII14 peptide synergistically augments the anti-cancer activity of chemotherapeutic drugs by activating pro-apoptotic Bim, PLoS One, 11(9), #e162525 (2016).
• Iyoda T, Matsunaga T, Fukai F. Integrin-dependent cell regulation and its clinical application. Encyclopedia of Biocolloid and Biointerface Science, Chapter 24, 313-, (2016).
• Tanaka R, Seki Y, ... Iyoda T, Fukai F, Tenascin-C-derived peptide TNIIIA2 highly enhances cell survival and platelet-derived growth factor (PDGF)-dependent cell proliferation through potentiated and sustained activation of integrin alpha5/beta1. J Biol Chem, 289(25), 17699-, doi: 10.1074/jbc.M113.546622. (2014).
• Iyoda T, ... Takada M, Fukai F, A novel mechanism underlying the basic defensive response of macrophages against Mycobacterium infection. J Immunol, 192(9), 4254-, doi: 10.4049/jimmunol.1301526. (2014).
• Matsunaga T, Iyoda T, Fukai F, Cell regulation through adhesion to extracellular matrix via adhesion molecule, integrins -Therapeutic application of integrin activation-modulating peptides-. Colloid and interface science in pharmaceutical research and development, 243-, (2014).
• Mera T, ... Iyoda T, ... Yasunami Y, Pretreatment of donor islets with the Na+/Ca2+ exchanger inhibitor improves the efficiency of islet transplantation. Am J Transplant, 13(8), 2154-, doi: 10.1111/ajt.12306. (2013).
• Hayashi R, ... Iyoda T, Fukai F, The cell adhesion and proliferation activities of a peptide derived from human tenascin-C are dependent on two Ile residues. Bioorg Med Chem, 20(15), 4608-, doi: 10.1016/j.bmc.2012.06.036. (2012).
• Iyoda T, ... Cui MZ, Lysophosphatidic acid induces early growth response-1 (Egr-1) protein expression via protein kinase C-delta-regulated extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activation in vascular smooth muscle cells. J Biol Chem, 287(27), 22635-, doi: 10.1074/jbc.M111.335695. (2012).
• Itagaki K, ... Iyoda T, Fukai F, Eukaryotic translation elongation factor 1A induces anoikis by triggering cell detachment. J Biol Chem, 287(19), 16037-, doi: 10.1074/jbc.M111.308122. (2012).
• Iyoda T, Fukai F, Modulation of tumor cell survival, proliferation, and differentiation by the peptide derived from tenascin-C: Implication of beta1-integrin activation. Int J Cell Biol, #647594, doi: 10.1155/2012/647594. (2012).
• Shiratsuchi Y, Iyoda T, ... Kobayashi Y, Infiltrating neutrophils induce allospecific CTL in response to immunization with apoptotic cells via MCP-1 production, K Leukoc Biol, 81(2), 412-, doi: 10.1189/jlb.0606399. (2007).
• Iyoda T, ... Kobayashi Y, Neutrophils accelerate macrophage-mediated digestion of apoptotic cells in vivo as well as in vitro. J Immunol, 175, 3475-, doi: 10.4049/jimmunol.175.6.3475. (2005).
• Iyoda T, Kobayashi Y, Involvement of MIP-2 and CXCR2 in neutrophil infiltration following injection of late apoptotic cells into the peritoneal cavity, Apoptosis, 9(4), 485-, doi: 10.1023/B:APPT.0000031450.95188.e7. (2004).

主な国際・国内活動

• 日本薬学会
• 日本免疫学会
• 日本生化学会
• 日本分子生物学会
• 日本がん分子標的治療学会
• 日本結合組織学会
• マトリセルフォーラム研究会（世話人）
• 中学/高校 教諭免許（理科, 一種/専修）
• 放射線取扱主任者 免許（第一種）
• 東京理科大学総合研究院　核酸医薬研究センター　客員教授
• 東京理科大学総合研究院　イノベーティブ DDS 創薬研究部門　客員教授